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Identifiers
 ; BHLHb31; CHF2; HERP2; HESR1; HRT-1; OAF1; hHRT1
External IDs
:  :  :  :
Molecular function
Cellular component
Biological process
RNA expression pattern
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
Hairy/enhancer-of-split related with YRPW motif protein 1 is a
that in humans is encoded by the HEY1 .
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.
Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev 85 (1–2): 173–7. :.  .
Kokubo H, Lun Y, Johnson RL (Aug 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochem Biophys Res Commun 260 (2): 459–65. :.  .
Iso T, Kedes L, Hamamori Y (2003). "HES and HERP families: multiple effectors of the Notch signaling pathway". J. Cell. Physiol. 194 (3): 237–55. :.  .
Kokubo H, Miyagawa-Tomita S, Johnson RL (2006). "Hesr, a mediator of the Notch signaling, functions in heart and vessel development". Trends Cardiovasc. Med. 15 (5): 190–4. :.  .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. :.  .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. :.  .
Chin MT, Maemura K, Fukumoto S et al. (2000). "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system". J. Biol. Chem. 275 (9): 6381–7. :.  .
Steidl C, Leimeister C, Klamt B et al. (2000). "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family". Genomics 66 (2): 195–203. :.  .
Maier MM, Gessler M (2000). "Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes". Biochem. Biophys. Res. Commun. 275 (2): 652–60. :.  .
Nakagawa O, McFadden DG, Nakagawa M et al. (2001). . Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13655–60. :.  .  .
Sun J, Kamei CN, Layne MD et al. (2001). "Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2". J. Biol. Chem. 276 (21): 18591–6. :.  .
Iso T, Sartorelli V, Chung G et al. (2001). . Mol. Cell. Biol. 21 (17): 6071–9. :.  .  .
Taylor KL, Henderson AM, Hughes CC (2003). "Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression". Microvasc. Res. 64 (3): 372–83. :.  .
Strausberg RL, Feingold EA, Grouse LH et al. (2003). . Proc. Natl. Acad. Sci. U.S.A. 99 (26): 1. :.  .  .
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. :.  .
Elagib KE, Xiao M, Hussaini IM et al. (2004). . Mol. Cell. Biol. 24 (17): 7779–94. :.  .  .
Suzuki Y, Yamashita R, Shirota M et al. (2004). . Genome Res. 14 (9): 1711–8. :.  .  .
Gerhard DS, Wagner L, Feingold EA et al. (2004). . Genome Res. 14 (10B): 2121–7. :.  .  .
Kokubo H, Miyagawa-Tomita S, Nakazawa M et al. (2005). "Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system". Dev. Biol. 278 (2): 301–9. :.  .
at the US National Library of Medicine
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hello或者hi，人名
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